Does Endometrial Ablation have a Role in Adenomyosis (1422)
The diagnoses of AUB-E and AUB-A are often confused, since the histological confirmation of adenomyosis is not possible by conservative measures1. Consequently, endometrial ablation is often used as a treatment modality, although the presence of adenomyosis may lead to a higher failure rate of ablation – up to 31%, with the diagnosis only made after further intervention such as hysterectomy is performed for women with ongoing bleeding symptoms2.
The use of diagnostic imaging such as ultrasound may be of some benefit in determining extensive adenomyoisis, although more subtle glandular infiltration of the myometrium is not always as easy to demonstrate3 with sensitivity and specificity of 80.8% and 61.4% respectively4. Superficial disease in the subendometrial layer may be adequately and completely treated by second generation ablation procedures, although the mechanism for these devices is to not infiltrate the myometrium deeply. For known deep disease, then resection as a primary modality may offer better post-operative outcomes, with sonographic or laparoscopic control both described as options for a deeper ablation procedure5,6.
Even in the absence of resective ablation, the technique may still be successful and therefore remains an option for women not wanting to undergo uterine removal. There is also the possibility of combination medical and surgical treatments (including progesterone containing IUD) to further decrease symptoms.
- Wood , C 1998, ‘Surgical and medical treatment of adenomyosis’, Human Reproduction Update, vol.4, no. 4, pp. 323-336
- Dickersin, K, Munro, M, Clark, M, Langenberg, P, Scherer, R, Frick, K, Hallock, L, Nichols, J, Yalcinkaya,T 2007, ‘Hysterectomy Compared with Endometrial Ablation for Dysfunctional Uterine Bleeding: A Randomized Control Trial’, Obstetrics and Gynecology, vol. 110, no. 6, pp. 1279-1289
- Dueholm , M, Lundorf, E 2007, ‘Transvaginal ultrasound or MRI for diagnosis of adenomyosis’, Current Opinion in Obstetrics and Gynecology, vol. 19, pp. 505-512
- Kepkep, K, Tuncay, Y, Goynumer, G, Tutal, E 2007, ‘Transvaginal sonography in the diagnosis of adenomyosis: which findings are most accurate?’, Ultrasound in Obstetrcis and Gynecology, vol. 30, pp. 341-345
- Preutthipan, S, Herabutya, Y 2010, ‘Hysteroscopic rollerball endometrial ablation as an alternative treatment for adenomyosis with menorrhagia and/or dysmenorrhea’, Journal of Obstetrics and Gynaecology Research, vol. 36, no. 5, pp. 1031-1036
- Zhou, M, Chen, JY, Tang, LD, Chen, WZ, Wang, ZB 2011, ‘Ultrasound-guided high-intensity focused ultrasound ablation for adenomyosis: the clinical experience of a single center’, Fertility and Sterility, vol. 95, no. 3, pp. 900-905